Endocrine Abstracts

Background: It is currently present in the literature that mitochondrial DNA (mtDNA) defects are associated with a great number of diseases including cancers. The role of mitochondrial DNA (mtDNA) mutations/variations in the development of thyroid cancers is a highly controversial topic. In this study, we aimed to investigate the role of mt-DNA control region (CR) variations in thyroid tumor occurrence and the influence of mtDNA haplogroups on susceptibility t...

ObjectiveScanty data about glucose metabolism, hypertension and metabolic syndrome (MS) have been reported in Paget’s disease of bone (PDB) to be related with increased cardiovascular mortality. We aimed to determine prevalence of metabolic syndrome in PDB and to determine the relationship between metabolic syndrome and bone-specific alkaline phosphatase levels.Patients and methodsTwenty three patients w...

ObjectivesPolycystic ovary syndrome (PCOS) is the most common reproductive disorder that onsets peripubertally and increases morbidity by affecting quality of life. Insulin like peptide 5 (INSL5) is a relaxine/insulin family member gut-peptide hormone that is expressed by various tissues including the hypothalamus, pituitary and ovary. In the present study, we aimed to characterize serum INSL5 levels in PCOS women and determine association of circulating...

IntroductionLangerhans cell histiocytosis (LCH) is a rare monoclonal disease characterized by abnormal proliferation and accumulation of bone marrow-derived Langerhans cells in various tissues. Heterogeneous collections of Langerhans cells with neutrophils, lymphocytes, eosinophils, histiocytes and Birbeck granules are observed in biopsy materials. Endocrinologic features of LCH are usually due to posterior pituitary involvement. Thyroid infiltration is ...

Introduction: Acromegaly is a disorder caused by excessive secretion of growth hormone, often due to pituitary masses. The first step in treatment is transsphenoidal surgery. Cabergoline, somatostatin receptor ligands or pegvisomant may be used in patients with an inadequate response after surgery. Finally, radiotherapy may be used in patients with inadequate response to medical treatment.Methods: In this retrospective study, data of 89 patients (59 fema...

Objective: Neurosteroids, a unique hormone group, are recognized for their impact on cognitive processes. The primary objective is to assess the correlation between cognitive function and NS levels in cases of Cushing’s disease and a control group of nonfunctional pituitary adenoma (NFPA).Design: The study comprised 26 individuals diagnosed with Cushing’s disease (CDG), while a control group (CG) consisted of 14 age-gender matched participants ...

Aim: Postoperative hypocalcemia is seen in 26-42% patients after parathyroidectomy.There are quite a lot of studies investigating preoperative factors that might be used to predict postoperative hypocalcemia in thyroidectomized patients, however there are less studies in parathyroidectomized patients.In this study, our aim was to determine whether any preoperative clinical, laboratory or ultrasonographical feature anticipate hypocalcemia in parathyroidectomized patients due to...

Introduction: Hypophysitis is a rare condition characterized by inflamation of the pituitary gland, causing mass effect and hypopituitarism. The incidence is estimated to be 1in9 million/year. The diagnosis of hypophysitis is based on clinical and laboratory findings, imaging methods and histopathology in selected cases. The aim of the treatment is to eliminate the compression effects of the mass and to treat hypopituitarsim. The first choice in medical treatment is immunsupre...

Introduction: Graves disease (GD) is an autoimmune disease in which thyrotropin receptor antibodies overactive the thyroid gland. Therefore, antithyroid drugs, radioactive iodine therapy, or surgical interventions are treatment options. In GD, pathology after thyroidectomy may include hypertrophy and hyperplasia in thyrocytes, mononuclear cell infiltration in the stroma, and increased blood supply. We presented a case with areas of necrosis and vasculitis due to GD in the path...

Introduction: While Graves’ disease is a common cause of thyrotoxicosis, tyroid hormone resistance (THR) is a rare cause of high thyroid hormones. Coexistence of Graves’ disease and THR which can cause quite a lot of difficulties in diagnosis and treatment was reported very rarely in the literature. Here, we report a patient with THR and Graves’ disease in whom remission was achieved with medical therapy.Case: A 38-year-old woman applied t...